The LINC Complex - Molekylärbiologi - häftad 9781493993673

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Linc complex

The Linc Complex book. Read reviews from world’s largest community for readers. This volume describes research methodologies and approaches used to study Stanford Libraries' official online search tool for books, media, journals, databases, government documents and more. KEY WORDS: LINC complex, Nuclear pore complex, Nups, SUN–KASH complex, Lamin, Nuclear envelope Introduction The genomic information in eukaryotic cells is protected by a double-layered nuclear membrane, which compartmentalizes the cell into two regions, the nucleus and the cytoplasm. The LINC complex (Linker of Nucleoskeleton and Cytoskeleton) is a protein complex associated with both inner and outer membranes of the nucleus. It is composed of SUN-domain proteins and KASH-domain proteins.

The LINC complex is made of Sad1/Unc84 (SUN) and Klarsicht/Anc1/Syne1 homology (KASH) proteins which have been recently characterized in plants. SUN proteins are located within the inner nuclear membrane, while the KASH proteins are included into the outer nuclear membrane. If 53BP1 interacts with the LINC complex, kinesin- and microtubule-dependent mobility of the LINC complex could alter the dynamic behavior of DSBs.

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Cristina Masoller, Universitat Politècnica de Catalunya, 08222, Barcelona, Spain This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no. 289447 While previous studies have implicated the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex in myonuclear positioning, and several mutations in LINC complex proteins indeed cause different skeletal muscle diseases in humans, the precise role of this complex in nuclear movement and positioning during muscle differentiation is still unclear (4 ⇓ ⇓ ⇓ ⇓ ⇓ ⇓ –11). To gain insight into potential functions of these putative LINC complex components, we compared their expression level based on publicly available Affymetrix data (Benedito et al., 2008; He et al., 2009; probes used are shown in Supplemental Table S1). Putative Medicago LINC complex components have a variety of expression levels in different M. The linker of nucleoskeleton to cytoskeleton (LINC) complex is an essential multi-protein structure spanning the nuclear envelope.

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The SUN-domain proteins are associated with both nuclear lamins and chromatin and cross the inner nuclear membrane. Recently, the LINC complex has been described for its role LInking the Nucleus to the Cytoskeleton and may play an important role in signaling and structural integrity. The LINC complex consists of large isoforms of nesprin-1 and -2 facing the cytoplasm. The nesprins are tethered to the outer nuclear membrane by interaction with SUN proteins. The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate J Biol Eng. 2019 Aug 7;13:68. doi: 10.1186/s13036-019-0197-9. 2021-03-29 · LINC complex ablation in mice reveals that LINC complexes are required to repress epidermal differentiation in vivo and in vitro and influence accessibility of epidermal differentiation genes, suggesting that force transduction from engaged integrins to the nucleus plays a role in maintaining keratinocyte progenitors.
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Helena Levander. and materials discovery, attacking cancer, understand complex natural ecosystems as well as man-made ecosystems such as the economy and technology. DG LINC. DG FINS.

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